STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
gch3GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (221 aa)    
Predicted Functional Partners:
Pcal_1124
PFAM: Creatininase; KEGG: pai:PAE2983 hypothetical protein.
    
 0.839
Pcal_1122
2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; KEGG: pai:PAE2985 riboflavin specific deaminase, putative; TIGRFAM: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase; PFAM: bifunctional deaminase-reductase domain protein.
       0.838
Pcal_0523
PFAM: nucleoside diphosphate kinase; KEGG: pai:PAE1561 nucleoside diphosphate kinase.
    
  0.801
Pcal_0029
PFAM: pyruvate kinase; KEGG: pai:PAE0819 pyruvate kinase; Belongs to the pyruvate kinase family.
     
  0.800
Pcal_0037
TIGRFAM: putative adenylyl cyclase CyaB; PFAM: adenylate cyclase; KEGG: pai:PAE0832 adenylate cyclase.
     
  0.800
Pcal_0237
PFAM: NUDIX hydrolase; KEGG: pai:PAE0252 diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (MutT/NUDIX family protein).
     
  0.800
Pcal_2125
PFAM: NUDIX hydrolase; KEGG: pai:PAE0714 diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (MutT/NUDIX family protein).
     
  0.800
Pcal_1121
PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; KEGG: pai:PAE2986 GTP cyclohydrolase II.
       0.751
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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