STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.998
Pcal_1403
PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: pai:PAE2648 pyruvate dehydrogenase E2 (dihydrolipoamide acetyltransferase).
 
  
 0.803
Pcal_1404
PFAM: Transketolase, central region; Transketolase domain protein; KEGG: pai:PAE2646 pyruvate dehydrogenase E1 beta subunit.
  
  
 0.757
Pcal_1402
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; tryptophan halogenase; KEGG: pai:PAE2649 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase).
  
 0.748
Pcal_1085
KEGG: pai:PAE2182 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase); TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family.
 
      0.747
Pcal_1405
PFAM: dehydrogenase, E1 component; KEGG: pai:PAE2644 pyruvate dehydrogenase E1 alpha subunit.
     
 0.746
Pcal_1408
PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: putative ABC-2 type transport system ATP-binding protein; K01990 ABC-2 type transport system ATP-binding protein.
     
 0.729
Pcal_1407
PFAM: ABC-2 type transporter.
       0.724
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.619
Pcal_1409
Thiosulfate sulfurtransferase; PFAM: Rhodanese domain protein; KEGG: pai:PAE2733 thiosulfate sulfurtransferase.
       0.603
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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