STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
endAtRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (184 aa)    
Predicted Functional Partners:
Pcal_2142
KEGG: pai:PAE0789 hypothetical protein.
    
 
 0.999
Pcal_1629
KEGG: pai:PAE2268 hypothetical protein.
       0.838
Pcal_1628
KEGG: pai:PAE2266 glycyl-tRNA synthetase; TIGRFAM: glycyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein.
 
    0.810
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
  
 
   0.771
pcn-2
Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
    0.611
nusA
NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family.
  
     0.595
trpS
KEGG: pai:PAE3091 tryptophanyl-tRNA synthetase; TIGRFAM: tryptophanyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase, class Ib.
 
   
 0.567
Pcal_1626
Agmatinase; TIGRFAM: putative agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: pai:PAE2260 agmatinase; Belongs to the arginase family.
       0.557
Pcal_0002
Cell division control protein 6; Involved in regulation of DNA replication.
  
     0.528
Pcal_0047
KEGG: pai:PAE0841 hypothetical protein.
    
 0.494
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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