STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (213 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
 0.999
Pcal_1886
KEGG: pai:PAE0224 hypothetical protein.
  
 0.999
Pcal_1899
Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; KEGG: pai:PAE0221 phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (purM).
 
 0.999
Pcal_1896
TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; KEGG: pai:PAE0219 phosphoribosylglycinamide formyltransferase.
 
 
 0.998
Pcal_1884
Amidophosphoribosyltransferase; PFAM: glutamine amidotransferase, class-II; phosphoribosyltransferase; KEGG: pai:PAE0226 amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.997
Pcal_1893
Amidophosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: pai:PAE0218 amidophosphoribosyltransferase (purF).
 
 
 0.994
Pcal_1894
Phosphoribosylamine--glycine ligase; KEGG: pai:PAE0216 phosphoribosylglycinamide synthetase (GARS) (purD); TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase.
 
  
 0.989
purK
5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
  
  
 0.987
purE
5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.987
purC
PFAM: SAICAR synthetase; KEGG: pai:PAE0215 phosphoribosylaminoimidazole-succinocarboxamide synthase (purC).
  
  
 0.987
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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