Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pcal_2001PFAM: Fmu (Sun) domain protein; KEGG: pai:PAE3578 sun family protein. (415 aa)    
Predicted Functional Partners:
rpl5
LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
  
 
 0.934
Pcal_1106
rRNA biogenesis protein Nop56/Nop58; PFAM: Pre-mRNA processing ribonucleoprotein, binding region; NOSIC; KEGG: pai:PAE3232 nop family pre-rRNA processing protein.
  
 
 0.919
Pcal_2161
PFAM: GTP-binding protein, HSR1-related; KEGG: pai:PAE0759 GTP binding protein, conjectural; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
 
 
 0.904
Pcal_2010
TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Nucleolar GTP-binding 1; Miro domain protein; KEGG: pai:PAE3626 hypothetical protein.
   
 
 0.871
rps8e
TIGRFAM: ribosomal protein S8e; PFAM: ribosomal protein S8E; KEGG: pai:PAE3331 ribosomal protein S8.
   
 
 0.843
rpl10
LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.
  
 
 0.828
rpl30
PFAM: ribosomal protein L30; KEGG: pai:PAE1183 ribosomal protein L30.
  
 
 0.820
rpl18
LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
 
 
 0.815
Pcal_0920
Ribosomal biogenesis protein, containing Brix domain; Probably involved in the biogenesis of the ribosome.
   
 
 0.814
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 
 0.805
Your Current Organism:
Pyrobaculum calidifontis
NCBI taxonomy Id: 410359
Other names: P. calidifontis JCM 11548, Pyrobaculum calidifontis JCM 11548, Pyrobaculum calidifontis VA1, Pyrobaculum calidifontis str. JCM 11548, Pyrobaculum calidifontis strain JCM 11548
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