| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GFO_0210 | GFO_0211 | GFO_0210 | GFO_0211 | OmpH family outer membrane protein. | OmpH family outer membrane protein. | 0.884 |
| GFO_0210 | murI | GFO_0210 | GFO_0209 | OmpH family outer membrane protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.617 |
| GFO_0210 | uppS | GFO_0210 | GFO_0213 | OmpH family outer membrane protein. | Undecaprenyl-pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.667 |
| GFO_0211 | GFO_0210 | GFO_0211 | GFO_0210 | OmpH family outer membrane protein. | OmpH family outer membrane protein. | 0.884 |
| GFO_0211 | murI | GFO_0211 | GFO_0209 | OmpH family outer membrane protein. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.544 |
| GFO_0211 | uppS | GFO_0211 | GFO_0213 | OmpH family outer membrane protein. | Undecaprenyl-pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.748 |
| GFO_1100 | alr | GFO_1100 | GFO_3353 | HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.536 |
| GFO_1100 | murI | GFO_1100 | GFO_0209 | HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.919 |
| GFO_1100 | uppS | GFO_1100 | GFO_0213 | HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Undecaprenyl-pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.645 |
| alr | GFO_1100 | GFO_3353 | GFO_1100 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.536 |
| alr | murD | GFO_3353 | GFO_2770 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.678 |
| alr | murI | GFO_3353 | GFO_0209 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.491 |
| ftsK | murD | GFO_2183 | GFO_2770 | DNA translocase. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.419 |
| ftsK | murI | GFO_2183 | GFO_0209 | DNA translocase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.743 |
| gdhA | glsA | GFO_0726 | GFO_2730 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutaminase; Belongs to the glutaminase family. | 0.908 |
| gdhA | gltB | GFO_0726 | GFO_2908 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate synthase (NADPH) large subunit. | 0.996 |
| gdhA | murI | GFO_0726 | GFO_0209 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.915 |
| glsA | gdhA | GFO_2730 | GFO_0726 | Glutaminase; Belongs to the glutaminase family. | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.908 |
| glsA | gltB | GFO_2730 | GFO_2908 | Glutaminase; Belongs to the glutaminase family. | Glutamate synthase (NADPH) large subunit. | 0.950 |
| glsA | murD | GFO_2730 | GFO_2770 | Glutaminase; Belongs to the glutaminase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.902 |