| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GFO_0283 | GFO_0284 | GFO_0283 | GFO_0284 | Protein containing DUF427. | Conserved hypothetical protein. | 0.873 |
| GFO_0283 | GFO_0285 | GFO_0283 | GFO_0285 | Protein containing DUF427. | Protein containing DUF323. | 0.812 |
| GFO_0283 | thyA | GFO_0283 | GFO_0288 | Protein containing DUF427. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.411 |
| GFO_0283 | tonB | GFO_0283 | GFO_0286 | Protein containing DUF427. | TonB protein. | 0.488 |
| GFO_0283 | tonB-2 | GFO_0283 | GFO_0287 | Protein containing DUF427. | TonB protein. | 0.444 |
| GFO_0284 | GFO_0283 | GFO_0284 | GFO_0283 | Conserved hypothetical protein. | Protein containing DUF427. | 0.873 |
| GFO_0284 | GFO_0285 | GFO_0284 | GFO_0285 | Conserved hypothetical protein. | Protein containing DUF323. | 0.996 |
| GFO_0284 | thyA | GFO_0284 | GFO_0288 | Conserved hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.454 |
| GFO_0284 | tonB | GFO_0284 | GFO_0286 | Conserved hypothetical protein. | TonB protein. | 0.516 |
| GFO_0284 | tonB-2 | GFO_0284 | GFO_0287 | Conserved hypothetical protein. | TonB protein. | 0.468 |
| GFO_0285 | GFO_0283 | GFO_0285 | GFO_0283 | Protein containing DUF323. | Protein containing DUF427. | 0.812 |
| GFO_0285 | GFO_0284 | GFO_0285 | GFO_0284 | Protein containing DUF323. | Conserved hypothetical protein. | 0.996 |
| GFO_0285 | thyA | GFO_0285 | GFO_0288 | Protein containing DUF323. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.479 |
| GFO_0285 | tonB | GFO_0285 | GFO_0286 | Protein containing DUF323. | TonB protein. | 0.529 |
| GFO_0285 | tonB-2 | GFO_0285 | GFO_0287 | Protein containing DUF323. | TonB protein. | 0.480 |
| thyA | GFO_0283 | GFO_0288 | GFO_0283 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Protein containing DUF427. | 0.411 |
| thyA | GFO_0284 | GFO_0288 | GFO_0284 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Conserved hypothetical protein. | 0.454 |
| thyA | GFO_0285 | GFO_0288 | GFO_0285 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | Protein containing DUF323. | 0.479 |
| thyA | tonB | GFO_0288 | GFO_0286 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | TonB protein. | 0.636 |
| thyA | tonB-2 | GFO_0288 | GFO_0287 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | TonB protein. | 0.703 |