| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GFO_1794 | GFO_2084 | GFO_1794 | GFO_2084 | Cysteine synthase/cystathionine beta-synthase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.909 |
| GFO_1794 | GFO_2397 | GFO_1794 | GFO_2397 | Cysteine synthase/cystathionine beta-synthase. | Cysteine synthase/cystathionine beta-synthase. | 0.902 |
| GFO_1794 | cysE | GFO_1794 | GFO_1531 | Cysteine synthase/cystathionine beta-synthase. | Serine O-acetyltransferase. | 0.968 |
| GFO_1794 | cysS | GFO_1794 | GFO_2741 | Cysteine synthase/cystathionine beta-synthase. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.834 |
| GFO_1794 | glyA | GFO_1794 | GFO_2262 | Cysteine synthase/cystathionine beta-synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.922 |
| GFO_1794 | hom | GFO_1794 | GFO_0318 | Cysteine synthase/cystathionine beta-synthase. | Homoserine dehydrogenase. | 0.823 |
| GFO_1794 | thrA | GFO_1794 | GFO_1970 | Cysteine synthase/cystathionine beta-synthase. | Bifunctional aspartokinase/homoserine dehydrogenase. | 0.854 |
| GFO_1794 | thrB | GFO_1794 | GFO_1969 | Cysteine synthase/cystathionine beta-synthase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.821 |
| GFO_1794 | trpB | GFO_1794 | GFO_2673 | Cysteine synthase/cystathionine beta-synthase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.907 |
| GFO_2084 | GFO_1794 | GFO_2084 | GFO_1794 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cysteine synthase/cystathionine beta-synthase. | 0.909 |
| GFO_2084 | GFO_2397 | GFO_2084 | GFO_2397 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cysteine synthase/cystathionine beta-synthase. | 0.909 |
| GFO_2084 | cysE | GFO_2084 | GFO_1531 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine O-acetyltransferase. | 0.912 |
| GFO_2084 | glyA | GFO_2084 | GFO_2262 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
| GFO_2084 | hom | GFO_2084 | GFO_0318 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine dehydrogenase. | 0.825 |
| GFO_2084 | thrA | GFO_2084 | GFO_1970 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Bifunctional aspartokinase/homoserine dehydrogenase. | 0.850 |
| GFO_2084 | thrB | GFO_2084 | GFO_1969 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.849 |
| GFO_2084 | trpB | GFO_2084 | GFO_2673 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| GFO_2397 | GFO_1794 | GFO_2397 | GFO_1794 | Cysteine synthase/cystathionine beta-synthase. | Cysteine synthase/cystathionine beta-synthase. | 0.902 |
| GFO_2397 | GFO_2084 | GFO_2397 | GFO_2084 | Cysteine synthase/cystathionine beta-synthase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.909 |
| GFO_2397 | cysE | GFO_2397 | GFO_1531 | Cysteine synthase/cystathionine beta-synthase. | Serine O-acetyltransferase. | 0.964 |