Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
spo0ASporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (263 aa)    
Predicted Functional Partners:
spoIVB
SpoIVB peptidase; KEGG: btl:BALH_3781 2.2e-49 spoIVB; stage IV sporulation protein B; COG: COG0750 Predicted membrane-associated Zn-dependent proteases 1; Psort location: Cytoplasmic, score: 8.87.
     0.946
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.801
sigK
RNA polymerase sigma-K factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.798
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.798
sigE
RNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.792
spoVT
Stage V sporulation protein T; COG: COG2002 Regulators of stationary/sporulation gene expression; Psort location: Cytoplasmic, score: 9.98.
  
   
 0.787
EDR47431.1
KEGG: ava:Ava_0744 0.00013 anti-sigma-factor antagonist (STAS) and sugar transfersase K00996; COG: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Psort location: Cytoplasmic, score: 8.87.
  
  
 0.786
spoIIID
Sporulation transcriptional regulator SpoIIID; COG: NOG13855 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.786
spoVAD
Stage V sporulation protein AD; KEGG: mma:MM0870 0.0025 acetyl-CoA acyltransferase K00632; COG: NOG06312 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.780
gpr
GPR endopeptidase; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
   
 0.774
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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