Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hydEIron-only hydrogenase maturation rSAM protein HydE; KEGG: bth:BT1835 1.2e-103 biotin synthetase K01012; COG: COG0502 Biotin synthase and related enzymes; Psort location: Cytoplasmic, score: 8.87. (349 aa)    
Predicted Functional Partners:
hydF
Hydrogenase maturation GTPase HydF; KEGG: hpa:HPAG1_1378 4.6e-14 putative thiophene/furan oxidation protein K00058; COG: COG1160 Predicted GTPases; Psort location: Cytoplasmic, score: 8.87.
   
 0.990
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.948
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
 
0.906
EDR47173.1
Putative iron-only hydrogenase system regulator; COG: NOG17852 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
 
    0.811
EDR47355.1
Hydrogenase, Fe-only; KEGG: mta:Moth_1717 5.5e-147 iron hydrogenase, small subunit K00336; COG: COG4624 Iron only hydrogenase large subunit, C-terminal domain; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.788
EDR46534.1
Hydrogenase, Fe-only; KEGG: tte:TTE0894 5.9e-143 nuoG; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) K00336; COG: COG4624 Iron only hydrogenase large subunit, C-terminal domain; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.744
EDR48505.1
Hypothetical protein; COG: COG4336 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87; Belongs to the D-glutamate cyclase family.
       0.497
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
     
 0.448
EDR48502.1
Nitroreductase family protein; KEGG: afu:AF0131 5.4e-14 NAD(P)H-flavin oxidoreductase, putative; COG: COG0778 Nitroreductase.
       0.438
EDR46533.1
4Fe-4S binding domain protein; KEGG: chy:CHY_0732 2.8e-200 hydB; Fe-hydrogenase, beta subunit K00335; COG: COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; Psort location: Cytoplasmic, score: 9.98.
 
     0.432
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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