Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sigERNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (246 aa)    
Predicted Functional Partners:
spoVT
Stage V sporulation protein T; COG: COG2002 Regulators of stationary/sporulation gene expression; Psort location: Cytoplasmic, score: 9.98.
  
    0.799
EDR47505.1
Sporulation initiation factor Spo0A domain protein; COG: COG0784 FOG: CheY-like receiver; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.798
spoIIID
Sporulation transcriptional regulator SpoIIID; COG: NOG13855 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
  
    0.796
spo0A
Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.792
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
   
 0.783
EDR48326.1
Sporulation protein, YlmC/YmxH family; COG: COG1873 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87.
 
     0.781
EDR47431.1
KEGG: ava:Ava_0744 0.00013 anti-sigma-factor antagonist (STAS) and sugar transfersase K00996; COG: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); Psort location: Cytoplasmic, score: 8.87.
  
   
 0.781
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
    0.779
spoIVB
SpoIVB peptidase; KEGG: btl:BALH_3781 2.2e-49 spoIVB; stage IV sporulation protein B; COG: COG0750 Predicted membrane-associated Zn-dependent proteases 1; Psort location: Cytoplasmic, score: 8.87.
  
     0.774
EDR47412.1
Putative stage V sporulation protein AE; COG: NOG13202 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.26.
  
     0.774
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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