STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)    
Predicted Functional Partners:
groS
Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
 
 
 0.999
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 0.987
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.983
EDR45946.1
Hsp90 protein; KEGG: hpa:HPAG1_0211 4.8e-61 chaperone and heat shock protein 90; COG: COG0326 Molecular chaperone, HSP90 family; Psort location: Cytoplasmic, score: 9.98.
   
 
 0.957
EDR47582.1
Lipid kinase, YegS/Rv2252/BmrU family; KEGG: eci:UTI89_C2362 4.9e-20 hypothetical protein; COG: COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase; Psort location: Cytoplasmic, score: 8.87.
    
  0.925
EDR47273.1
Lipid kinase, YegS/Rv2252/BmrU family; KEGG: cal:orf19.5257 7.4e-08 LCB4; sphingolipid long chain base kinase K04718; COG: COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase; Psort location: Cytoplasmic, score: 8.87.
    
  0.925
EDR45797.1
Peptidase M16 inactive domain protein; KEGG: hdu:HD0187 1.7e-09 ptrA; protease III K01407; COG: COG1026 Predicted Zn-dependent peptidases, insulinase-like; Psort location: Cytoplasmic, score: 8.87.
   
  0.911
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.908
EDR46654.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.880
EDR46849.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.880
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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