Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sdaAAKEGG: cno:NT01CX_1254 4.8e-61 sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87. (289 aa)    
Predicted Functional Partners:
sdaAB
L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 4.5e-49 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
 0.999
sdaAB-2
L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 2.0e-53 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.937
glyA-2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.937
ilvA
KEGG: fnu:FN1411 1.5e-114 threonine dehydratase K01754; COG: COG1171 Threonine dehydratase.
  
 
 0.920
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.910
cysE
KEGG: chy:CHY_2339 6.4e-66 cysE; serine acetyltransferase K00640; COG: COG1045 Serine acetyltransferase; Psort location: Cytoplasmic, score: 9.98.
     
 0.908
thrH
KEGG: hch:HCH_02661 1.1e-54 thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.907
sdaAA-2
KEGG: chy:CHY_2457 3.0e-59 sdhA2; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.900
EDR48040.1
KEGG: swo:Swol_1319 6.6e-80 homoserine dehydrogenase K00003; COG: COG0460 Homoserine dehydrogenase; Psort location: Cytoplasmic, score: 8.87.
   
 
  0.801
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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