trpA protein (Dorea formicigenerans) - STRING interaction network

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trpA

Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (218 aa)

Predicted Functional Partners:

EDR47305.1

0.987

glyA

0.922

glyA-2

0.922

ilvA

0.917

sdaAB

0.910

sdaAA

0.910

sdaAB-2

0.910

sdaAA-2

0.910

EDR47306.1

0.903

thrH

0.903

Your Current Organism:

Dorea formicigenerans

NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDR47305.1	EDR47306.1	DORFOR_01271	DORFOR_01272	Hypothetical protein; KEGG: ppd:Ppro_1582 1.1e-18 anthranilate synthase component I K01656; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein.	0.714
EDR47305.1	trpA	DORFOR_01271	DORFOR_01270	Hypothetical protein; KEGG: ppd:Ppro_1582 1.1e-18 anthranilate synthase component I K01656; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score: 8.87.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.987
EDR47306.1	EDR47305.1	DORFOR_01272	DORFOR_01271	Hypothetical protein.	Hypothetical protein; KEGG: ppd:Ppro_1582 1.1e-18 anthranilate synthase component I K01656; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: Cytoplasmic, score: 8.87.	0.714
EDR47306.1	trpA	DORFOR_01272	DORFOR_01270	Hypothetical protein.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.903
glyA	glyA-2	DORFOR_00891	DORFOR_02150	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.902
glyA	ilvA	DORFOR_00891	DORFOR_01477	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: fnu:FN1411 1.5e-114 threonine dehydratase K01754; COG: COG1171 Threonine dehydratase.	0.917
glyA	sdaAA	DORFOR_00891	DORFOR_00981	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: cno:NT01CX_1254 4.8e-61 sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87.	0.937
glyA	sdaAA-2	DORFOR_00891	DORFOR_02159	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: chy:CHY_2457 3.0e-59 sdhA2; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87.	0.937
glyA	sdaAB	DORFOR_00891	DORFOR_00980	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 4.5e-49 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.937
glyA	sdaAB-2	DORFOR_00891	DORFOR_02158	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 2.0e-53 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.937
glyA	thrH	DORFOR_00891	DORFOR_02046	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: hch:HCH_02661 1.1e-54 thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.87.	0.932
glyA	trpA	DORFOR_00891	DORFOR_01270	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.922
glyA-2	glyA	DORFOR_02150	DORFOR_00891	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.902
glyA-2	ilvA	DORFOR_02150	DORFOR_01477	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: fnu:FN1411 1.5e-114 threonine dehydratase K01754; COG: COG1171 Threonine dehydratase.	0.917
glyA-2	sdaAA	DORFOR_02150	DORFOR_00981	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: cno:NT01CX_1254 4.8e-61 sdaAA; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87.	0.937
glyA-2	sdaAA-2	DORFOR_02150	DORFOR_02159	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: chy:CHY_2457 3.0e-59 sdhA2; L-serine dehydratase, iron-sulfur-dependent, alpha subunit K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87.	0.950
glyA-2	sdaAB	DORFOR_02150	DORFOR_00980	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 4.5e-49 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.937
glyA-2	sdaAB-2	DORFOR_02150	DORFOR_02158	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-serine dehydratase, iron-sulfur-dependent, beta subunit; KEGG: tte:TTE1008 2.0e-53 sdaA; L-serine deaminase K01752; COG: COG1760 L-serine deaminase; Psort location: Cytoplasmic, score: 8.87; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.950
glyA-2	thrH	DORFOR_02150	DORFOR_02046	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	KEGG: hch:HCH_02661 1.1e-54 thrH; phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: Cytoplasmic, score: 8.87.	0.932
glyA-2	trpA	DORFOR_02150	DORFOR_01270	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.922

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