Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (363 aa)    
Predicted Functional Partners:
recX
Regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.
  
 
 0.985
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.977
EDR45655.1
Topoisomerase DNA-binding C4 zinc finger domain protein; KEGG: pab:PAB1430 5.2e-06 topA; DNA topoisomerase I K03168; COG: COG0514 Superfamily II DNA helicase; Psort location: Cytoplasmic, score: 8.87.
  
 0.951
lexA
Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
 
 0.925
EDR47568.1
KEGG: ctc:CTC00579 3.0e-107 sbcC; exonuclease sbcC K03546; COG: COG0419 ATPase involved in DNA repair; Psort location: Cytoplasmic, score: 9.98.
   
 0.914
EDR46261.1
Hypothetical protein; KEGG: cal:orf19.2417 2.5e-07 SMC5; structural maintenance of chromosomes protein K01553; COG: COG4717 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87.
   
 0.910
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.901
EDR45661.1
DNA-binding helix-turn-helix protein; KEGG: blo:BL0712 5.4e-06 aspartate aminotransferase K00812; COG: COG1396 Predicted transcriptional regulators; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.900
EDR46519.1
DNA-binding helix-turn-helix protein; KEGG: blo:BL0712 1.1e-05 aspartate aminotransferase K00812; COG: COG1396 Predicted transcriptional regulators; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.900
sbcD
Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.885
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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