Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
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nifSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (393 aa)    
Predicted Functional Partners:
nifU
Fe-S iron-sulfur cluster assembly protein, NifU family; KEGG: rxy:Rxyl_1354 1.2e-20 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: Cytoplasmic, score: 8.87.
 
 0.998
EDR47920.1
Hypothetical protein; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: Cytoplasmic, score: 8.87.
  
 0.977
EDR48396.1
Hypothetical protein; COG: NOG13230 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87; Belongs to the sulfur carrier protein TusA family.
   
 0.972
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.967
EDR47844.1
Aminotransferase, class V; KEGG: tte:TTE1663 1.2e-105 nifS; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes K04487; COG: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.909
EDR46936.1
Transcriptional regulator, Rrf2 family; KEGG: ama:AM656 1.2e-08 aminotransferase, class V K04487; COG: COG1959 Predicted transcriptional regulator; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.868
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.852
EDR46349.1
ThiF family protein; KEGG: hpa:HPAG1_0799 3.4e-60 thiamine biosynthesis protein; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; Psort location: Cytoplasmic, score: 8.87.
   
 0.829
selD
KEGG: cpf:CPF_2374 2.4e-82 selD; selenide, water dikinase K01008; COG: COG0709 Selenophosphate synthase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.737
yedF
Selenium metabolism protein YedF; COG: NOG13230 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87; Belongs to the sulfur carrier protein TusA family.
   
 
 0.735
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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