STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (205 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.987
dinB
ImpB/MucB/SamB family protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.700
EDR46099.1
ImpB/MucB/SamB family protein; KEGG: btl:BALH_p0040 2.4e-59 uvrX; DNA-damage repair protein (DNA polymerase IV) K00961; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.685
EDR47978.1
ImpB/MucB/SamB family protein; KEGG: btl:BALH_p0040 6.9e-37 uvrX; DNA-damage repair protein (DNA polymerase IV) K00961; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.644
EDR47068.1
LysM domain protein; KEGG: lmf:LMOf2365_2670 3.9e-05 autolysin K01446; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.589
recN
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.588
EDR47071.1
Integrase core domain protein; COG: COG2801 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87.
 
    0.585
EDR48620.1
Transcriptional regulator, AraC family; KEGG: bce:BC3740 8.0e-11 ADA regulatory protein K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: Cytoplasmic, score: 9.65.
   
   0.520
EDR47070.1
Transposase; COG: COG2963 Transposase and inactivated derivatives; Psort location: Cytoplasmic, score: 8.87.
       0.513
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
  
 0.454
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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