STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase; KEGG: cno:NT01CX_2118 1.8e-171 purB; adenylosuccinate lyase K01756; COG: COG0015 Adenylosuccinate lyase; Psort location: Cytoplasmic, score: 8.87.
 
 0.998
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.990
EDR47701.1
Phosphoribosylformylglycinamidine synthase; KEGG: cac:CAC1655 0. purQ, purL; bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain) K01952; COG: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.984
EDR45943.1
AICARFT/IMPCHase bienzyme; KEGG: dme:Dmel_CG11089 3.3e-124 CG11089 K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.87.
  
 0.975
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
 
  
 0.921
hpt
KEGG: tte:TTE2394 5.0e-43 hpt; hypoxanthine-guanine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.900
argG
KEGG: lma:LmjF23.0260 3.0e-132 argininosuccinate synthase, putative K01940; COG: COG0137 Argininosuccinate synthase; Psort location: Cytoplasmic, score: 8.87; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.894
pyrB
KEGG: cac:CAC2654 8.0e-107 aspartate carbamoyltransferase catalytic subunit K00609; COG: COG0540 Aspartate carbamoyltransferase, catalytic chain; Psort location: Cytoplasmic, score: 9.98; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
  
 
 0.893
EDR45850.1
Aminotransferase, class I/II; KEGG: cac:CAC2832 5.0e-114 PLP-dependent aminotransferase K00811; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: Cytoplasmic, score: 8.87.
   
 0.877
EDR47654.1
5'-nucleotidase, C-terminal domain protein; KEGG: afu:AF0876 6.5e-57 nt5; 5'-nucleotidase (nt5) K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.
    
 0.876
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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