STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (407 aa)    
Predicted Functional Partners:
pgi
KEGG: gka:GK2924 1.7e-161 glucose-6-phosphate isomerase K01810; COG: COG0166 Glucose-6-phosphate isomerase; Psort location: Cytoplasmic, score: 9.98; Belongs to the GPI family.
  
 0.987
fba
KEGG: cpf:CPF_1557 1.0e-113 fba; fructose-1,6-bisphosphate aldolase, class II K01624; COG: COG0191 Fructose/tagatose bisphosphate aldolase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.955
pfkA-2
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
  
  
0.888
fbp-2
KEGG: cno:NT01CX_1512 2.5e-167 fructose-1,6-bisphosphatase K01086; COG: COG3855 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
     
 0.887
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
0.881
pfkB
1-phosphofructokinase; KEGG: cno:NT01CX_1725 3.2e-87 1-phosphofructokinase K00882; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: Cytoplasmic, score: 8.87; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
     
 0.871
fsa
Fructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.867
rpiB
KEGG: sth:STH2337 5.9e-56 ribose 5-phosphate isomerase K01808; COG: COG0698 Ribose 5-phosphate isomerase RpiB; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.856
EDR46321.1
Transketolase, thiamine diphosphate binding domain protein; KEGG: mmp:MMP1115 2.1e-76 transketolase, N terminal half K00615; COG: COG3959 Transketolase, N-terminal subunit.
    
 0.853
EDR46322.1
Transketolase, pyridine binding domain protein; KEGG: chy:CHY_0166 2.3e-84 putative transketolase, C-terminal subunit K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: Cytoplasmic, score: 8.87.
    
  0.851
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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