mprF protein (Dorea formicigenerans) - STRING interaction network

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mprF

Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. (343 aa)

Predicted Functional Partners:

EDR45628.1

0.908

EDR45626.1

0.883

psd

0.785

EDR46566.1

0.514

EDR47856.1

0.501

EDR47484.1

0.484

EDR47298.1

0.448

EDR47950.1

0.437

EDR45629.1

0.422

murG

0.421

Your Current Organism:

Dorea formicigenerans

NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDR45626.1	EDR45628.1	DORFOR_02227	DORFOR_02229	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	0.891
EDR45626.1	EDR45629.1	DORFOR_02227	DORFOR_02230	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87.	0.401
EDR45626.1	mprF	DORFOR_02227	DORFOR_02228	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.883
EDR45626.1	psd	DORFOR_02227	DORFOR_02226	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	KEGG: cac:CAC0799 4.1e-55 psd; phosphatidylserine decarboxylase K01613; COG: COG0688 Phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family.	0.991
EDR45628.1	EDR45626.1	DORFOR_02229	DORFOR_02227	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	0.891
EDR45628.1	EDR45629.1	DORFOR_02229	DORFOR_02230	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87.	0.422
EDR45628.1	mprF	DORFOR_02229	DORFOR_02228	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.908
EDR45628.1	psd	DORFOR_02229	DORFOR_02226	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	KEGG: cac:CAC0799 4.1e-55 psd; phosphatidylserine decarboxylase K01613; COG: COG0688 Phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family.	0.847
EDR45629.1	EDR45626.1	DORFOR_02230	DORFOR_02227	Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87.	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	0.401
EDR45629.1	EDR45628.1	DORFOR_02230	DORFOR_02229	Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87.	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	0.422
EDR45629.1	mprF	DORFOR_02230	DORFOR_02228	Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.422
EDR46566.1	mprF	DORFOR_01789	DORFOR_02228	Acetyltransferase, GNAT family; KEGG: ldb:Ldb1165 2.0e-53 acyltransferase K00680; COG: COG1247 Sortase and related acyltransferases; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.514
EDR47298.1	mprF	DORFOR_01264	DORFOR_02228	Hypothetical protein; KEGG: sec:SC1961 4.7e-11 fliB; N-methylation of lysine residues in flagellin K00599; COG: NOG18602 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.448
EDR47484.1	mprF	DORFOR_01009	DORFOR_02228	Hypothetical protein; COG: NOG21901 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.484
EDR47856.1	mprF	DORFOR_00939	DORFOR_02228	Glycosyltransferase, group 2 family protein; KEGG: gbe:GbCGDNIH1_2152 1.6e-68 glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: Cytoplasmic, score: 8.87.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.501
EDR47856.1	murG	DORFOR_00939	DORFOR_02805	Glycosyltransferase, group 2 family protein; KEGG: gbe:GbCGDNIH1_2152 1.6e-68 glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: Cytoplasmic, score: 8.87.	Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.	0.406
EDR47950.1	mprF	DORFOR_00607	DORFOR_02228	Alcohol acetyltransferase; COG: NOG32388 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.97.	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	0.437
mprF	EDR45626.1	DORFOR_02228	DORFOR_02227	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 1.0e-33 phosphatidylserine synthase K00998; COG: COG1183 Phosphatidylserine synthase; Psort location: CytoplasmicMembrane, score: 9.99.	0.883
mprF	EDR45628.1	DORFOR_02228	DORFOR_02229	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	PAP2 family protein; KEGG: eci:UTI89_C1633 6.3e-05 ynbD; putative enzyme YnbD K01104; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: CytoplasmicMembrane, score: 9.26.	0.908
mprF	EDR45629.1	DORFOR_02228	DORFOR_02230	Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.	Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87.	0.422

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