STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDR45629.1Methionine synthase, vitamin-B12 independent; KEGG: lsl:LSL_0129 3.3e-69 metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase K00549; COG: COG0620 Methionine synthase II (cobalamin-independent); Psort location: Cytoplasmic, score: 8.87. (381 aa)    
Predicted Functional Partners:
EDR48544.1
KEGG: ctc:CTC01806 6.6e-199 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.919
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.856
metF
KEGG: mxa:MXAN_3039 1.4e-68 metF; 5,10-methylenetetrahydrofolate reductase; COG: COG0685 5,10-methylenetetrahydrofolate reductase; Psort location: Cytoplasmic, score: 8.87.
  
 0.837
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.789
luxS
S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
 
  
 0.728
EDR46998.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; KEGG: bth:BT1923 1.5e-176 O-acetylhomoserine (thiol)-lyase K01740; COG: COG2873 O-acetylhomoserine sulfhydrylase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.637
EDR46344.1
Hypothetical protein; KEGG: gme:Gmet_1566 1.7e-23 Cys/Met metabolism pyridoxal-phosphate-dependent enzyme K01740; COG: COG2873 O-acetylhomoserine sulfhydrylase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.637
EDR45479.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; KEGG: bth:BT2387 5.7e-168 O-acetylhomoserine (thiol)-lyase K01740; COG: COG2873 O-acetylhomoserine sulfhydrylase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.637
EDR45630.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
       0.601
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.481
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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