STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDR45655.1Topoisomerase DNA-binding C4 zinc finger domain protein; KEGG: pab:PAB1430 5.2e-06 topA; DNA topoisomerase I K03168; COG: COG0514 Superfamily II DNA helicase; Psort location: Cytoplasmic, score: 8.87. (365 aa)    
Predicted Functional Partners:
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.997
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.990
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.987
sbcD
Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.980
EDR46260.1
Hypothetical protein; KEGG: gox:GOX1019 1.6e-06 putative exonuclease K01146; COG: COG0420 DNA repair exonuclease; Psort location: Cytoplasmic, score: 8.87.
   
 0.980
EDR47148.1
DNA topoisomerase; KEGG: cac:CAC3567 6.1e-93 topB; topoisomerase B K03169; COG: COG0550 Topoisomerase IA; Psort location: Cytoplasmic, score: 8.87.
   
 0.971
EDR46888.1
DNA topoisomerase; KEGG: efa:EF2312 4.7e-189 topB-2; DNA topoisomerase III K03169; COG: COG0550 Topoisomerase IA; Psort location: Cytoplasmic, score: 8.87.
   
 0.971
EDR46077.1
DNA topoisomerase; KEGG: efa:EF2312 1.4e-164 topB-2; DNA topoisomerase III K03169; COG: COG0550 Topoisomerase IA; Psort location: Cytoplasmic, score: 8.87.
   
 0.971
EDR45414.1
Hypothetical protein; KEGG: efa:EF2312 9.1e-51 topB-2; DNA topoisomerase III K03169; COG: COG0550 Topoisomerase IA; Psort location: Cytoplasmic, score: 8.87.
   
 0.971
EDR45426.1
DNA topoisomerase; KEGG: efa:EF2312 2.7e-145 topB-2; DNA topoisomerase III K03169; COG: COG0550 Topoisomerase IA; Psort location: Cytoplasmic, score: 8.87.
   
 0.971
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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