STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)    
Predicted Functional Partners:
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
 0.986
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.938
deoD
KEGG: bcl:ABC4021 8.9e-76 deoD; purine-nucleoside phosphorylase K03784; COG: COG0813 Purine-nucleoside phosphorylase; Psort location: Cytoplasmic, score: 8.87.
    
 0.933
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.929
EDR46207.1
Hypothetical protein; KEGG: fnu:FN2033 9.3e-10 guanylate kinase K00942; COG: COG0194 Guanylate kinase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.916
EDR47182.1
Putative permease; KEGG: art:Arth_3333 0.0019 carbonate dehydratase K01672; COG: COG2233 Xanthine/uracil permeases; Psort location: CytoplasmicMembrane, score: 10.00.
  
 0.913
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
     
 0.905
hpt
KEGG: tte:TTE2394 5.0e-43 hpt; hypoxanthine-guanine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
   
 0.888
rdgB
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
   
 0.882
EDR47956.1
KEGG: mta:Moth_1960 2.2e-120 aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding K00087; COG: COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs; Psort location: CytoplasmicMembrane, score: 9.49.
 
  
  0.879
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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