Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
addAdenosine deaminase; KEGG: efa:EF0171 6.3e-59 add; adenosine deaminase K01488; COG: COG1816 Adenosine deaminase; Psort location: Cytoplasmic, score: 8.87. (311 aa)    
Predicted Functional Partners:
EDR46455.1
RelA/SpoT domain protein; KEGG: stc:str0145 1.7e-05 relA; (p)ppGpp synthetase K00951; COG: COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; Psort location: Cytoplasmic, score: 8.87.
       0.682
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
  
  
 0.576
EDR47654.1
5'-nucleotidase, C-terminal domain protein; KEGG: afu:AF0876 6.5e-57 nt5; 5'-nucleotidase (nt5) K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.
    
 0.572
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.562
deoD
KEGG: bcl:ABC4021 8.9e-76 deoD; purine-nucleoside phosphorylase K03784; COG: COG0813 Purine-nucleoside phosphorylase; Psort location: Cytoplasmic, score: 8.87.
    
 0.556
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
 
 0.525
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
   
 
 0.525
EDR46453.1
Hypothetical protein; KEGG: eci:UTI89_C1400 5.8e-15 ychM; putative sulfate transporter YchM K03321; COG: COG0659 Sulfate permease and related transporters (MFS superfamily).
       0.501
EDR46456.1
Hypothetical protein; KEGG: ljo:LJ1120 0.0048 alcohol dehydrogenase K00001; COG: COG2378 Predicted transcriptional regulator.
       0.461
EDR47468.1
Hypothetical protein; KEGG: mmu:15204 0.00013 Herc2; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 K03874; COG: KOG1426 FOG: RCC1 domain; Psort location: Cytoplasmic, score: 8.87.
    
 
 0.447
Your Current Organism:
Dorea formicigenerans
NCBI taxonomy Id: 411461
Other names: D. formicigenerans ATCC 27755, Dorea formicigenerans ATCC 27755
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