STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (390 aa)    
Predicted Functional Partners:
EDM99398.1
Aminotransferase, class V; KEGG: mta:Moth_0199 9.1e-83 aminotransferase, class V K04487; COG: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
 0.957
sun
Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
   
    0.954
nifS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
 0.938
EDN01443.1
Mg chelatase-like protein; KEGG: chu:CHU_0354 5.4e-124 ch1I; magnesium chelatase, subunit ChlI K07391; COG: COG0606 Predicted ATPase with chaperone activity; Psort location: Cytoplasmic, score:8.96.
       0.681
trmU
KEGG: mxa:MXAN_3499 2.0e-62 trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566; COG: COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain; Psort location: Cytoplasmic, score:8.96.
  
 
 0.608
EDN01442.1
Hypothetical protein; KEGG: bce:BC0888 1.1e-08 N-acetylmuramoyl-L-alanine amidase K01447; COG: COG3291 FOG: PKD repeat.
 
     0.599
cinA
Competence/damage-inducible domain protein CinA; KEGG: mmu:319945 5.5e-07 Flad1; RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: Cytoplasmic, score:8.96; Belongs to the CinA family.
    
 0.594
miaB
(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB family protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
   
  
 0.590
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.569
EDM97927.1
Hypothetical protein; KEGG: ctc:CTC02272 2.2e-26 purine nucleoside phosphorylase K00755; COG: COG1683 Uncharacterized conserved protein.
 
     0.538
Your Current Organism:
Pseudoflavonifractor capillosus
NCBI taxonomy Id: 411467
Other names: Bacteroides capillosus ATCC 29799, P. capillosus ATCC 29799, Pseudoflavonifractor capillosus ATCC 29799, Pseudoflavonifractor capillosus str. ATCC 29799, Pseudoflavonifractor capillosus strain ATCC 29799
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