STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDN00074.1UvrD/REP helicase; KEGG: tte:TTE0604 1.6e-117 uvrD; Superfamily I DNA and RNA helicases K03657; COG: COG0210 Superfamily I DNA and RNA helicases. (717 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 
 0.868
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.856
EDM99019.1
KEGG: cpf:CPF_0327 2.9e-70 recQ; ATP-dependent DNA helicase RecQ K03654; COG: COG0514 Superfamily II DNA helicase.
 
 0.852
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.845
EDN01209.1
DEAD/DEAH box helicase; KEGG: lic:LIC12689 2.4e-19 ATP-dependent DNA helicase K03654; COG: COG0514 Superfamily II DNA helicase; Psort location: Cytoplasmic, score:8.96.
  
 0.819
mutL
Putative DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 
 0.791
EDM97983.1
UvrD/REP helicase; KEGG: ctc:CTC00692 1.3e-74 DNA helicase II K01529; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score:8.96.
  
  
 
0.721
EDM98714.1
KEGG: bha:BH0648 6.1e-164 pcrA; ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: Cytoplasmic, score:8.96.
  
  
 
0.706
EDN00075.1
ABC transporter, ATP-binding protein; KEGG: ava:Ava_3020 7.2e-138 ABC transporter-like K06020; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: CytoplasmicMembrane, score:7.88.
       0.675
EDN00076.1
Hypothetical protein; Psort location: Cytoplasmic, score:8.96.
       0.675
Your Current Organism:
Pseudoflavonifractor capillosus
NCBI taxonomy Id: 411467
Other names: Bacteroides capillosus ATCC 29799, P. capillosus ATCC 29799, Pseudoflavonifractor capillosus ATCC 29799, Pseudoflavonifractor capillosus str. ATCC 29799, Pseudoflavonifractor capillosus strain ATCC 29799
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