Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
spo0ASporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (263 aa)    
Predicted Functional Partners:
spoIVB
SpoIVB peptidase; KEGG: btl:BALH_3781 9.1e-51 spoIVB; stage IV sporulation protein B; COG: COG0750 Predicted membrane-associated Zn-dependent proteases 1.
     0.950
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
  
 0.822
spoIIR
Stage II sporulation protein R; COG: NOG13215 non supervised orthologous group.
  
   
 0.819
EDS08104.1
Stage III sporulation protein AA; COG: COG3854 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
 
   
 0.811
EDS08110.1
Putative stage III sporulation protein AG; COG: NOG11553 non supervised orthologous group.
 
   
 0.802
EDS08107.1
Stage III sporulation protein AD; COG: NOG13205 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.99.
 
   
 0.793
spoIVA
Stage IV sporulation protein A; COG: NOG05962 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.793
sigK
RNA polymerase sigma-K factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.792
sigE
RNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.792
spoVAD
Stage V sporulation protein AD; COG: NOG06312 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.75.
  
   
 0.784
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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