Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
recURecombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (166 aa)    
Predicted Functional Partners:
rluC
Pseudouridine synthase, RluA family; KEGG: cpe:CPE1204 1.3e-51 ribosomal large subunit pseudouridine synthase C K06179; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific; Psort location: Cytoplasmic, score: 8.87; Belongs to the pseudouridine synthase RluA family.
 
     0.849
EDS08153.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 7.80.
       0.723
RsuA
Pseudouridylate synthase; KEGG: tte:TTE0052 3.6e-63 rsuA; 16S rRNA uridine-516 pseudouridylate synthase and related Pseudouridylate synthase K06183; COG: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Psort location: Cytoplasmic, score: 8.87; Belongs to the pseudouridine synthase RsuA family.
  
    0.717
RsmF
NOL1/NOP2/sun family protein; KEGG: lsl:LSL_0999 8.9e-76 putative 23S rRNA m(5)C methyltransferase K00599; COG: COG3270 Uncharacterized conserved protein; Psort location: Cytoplasmic, score: 8.87.
       0.705
EDS08151.1
Putative radical SAM protein YgiQ; KEGG: fnu:FN0734 4.3e-131 Fe-S oxidoreductase; COG: COG1032 Fe-S oxidoreductase; Psort location: Cytoplasmic, score: 8.87.
       0.705
EDS07942.1
Hypothetical protein; Psort location: Cytoplasmic, score: 8.87.
  
     0.695
EDS05745.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.75.
  
     0.691
hisZ
ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
       0.666
isfD
KEGG: nwi:Nwi_0477 2.7e-35 short-chain dehydrogenase/reductase SDR; COG: COG0300 Short-chain dehydrogenases of various substrate specificities; Psort location: Cytoplasmic, score: 9.98; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.651
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
       0.646
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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