Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nnrYjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (505 aa)    
Predicted Functional Partners:
act
Hydrolase, NUDIX family; KEGG: gka:GK2320 9.4e-33 ADP-ribose pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.87.
  
 0.967
cshA
DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87.
  
 0.952
alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
 
    0.879
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
   0.774
hndC_3
4Fe-4S binding domain protein; KEGG: swo:Swol_1701 3.0e-194 NADH dehydrogenase (quinone) K05903; COG: COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; Psort location: Cytoplasmic, score: 9.98.
  
   0.752
tsaE
Hydrolase, P-loop family; KEGG: cjk:jk1734 6.8e-13 alr; hypothetical protein K01775; COG: COG0802 Predicted ATPase or kinase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.737
CorC_3
CBS domain protein; KEGG: hpa:HPAG1_1423 2.3e-38 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: Cytoplasmic, score: 8.87.
       0.664
ndoA_2
Toxin-antitoxin system, toxin component, MazF family; Toxic component of a type II toxin-antitoxin (TA) system.
       0.661
rex
CoA binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
       0.658
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.650
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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