| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CorC_3 | alr | CLOSCI_00609 | CLOSCI_00611 | CBS domain protein; KEGG: hpa:HPAG1_1423 2.3e-38 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: Cytoplasmic, score: 8.87. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.676 |
| CorC_3 | ndoA_2 | CLOSCI_00609 | CLOSCI_00610 | CBS domain protein; KEGG: hpa:HPAG1_1423 2.3e-38 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: Cytoplasmic, score: 8.87. | Toxin-antitoxin system, toxin component, MazF family; Toxic component of a type II toxin-antitoxin (TA) system. | 0.720 |
| CorC_3 | nnr | CLOSCI_00609 | CLOSCI_00612 | CBS domain protein; KEGG: hpa:HPAG1_1423 2.3e-38 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: Cytoplasmic, score: 8.87. | YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.668 |
| CorC_3 | rex | CLOSCI_00609 | CLOSCI_00613 | CBS domain protein; KEGG: hpa:HPAG1_1423 2.3e-38 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: Cytoplasmic, score: 8.87. | CoA binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. | 0.550 |
| act | cshA | CLOSCI_01396 | CLOSCI_00330 | Hydrolase, NUDIX family; KEGG: gka:GK2320 9.4e-33 ADP-ribose pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.87. | DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | 0.936 |
| act | nadE | CLOSCI_01396 | CLOSCI_01169 | Hydrolase, NUDIX family; KEGG: gka:GK2320 9.4e-33 ADP-ribose pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.87. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.453 |
| act | nnr | CLOSCI_01396 | CLOSCI_00612 | Hydrolase, NUDIX family; KEGG: gka:GK2320 9.4e-33 ADP-ribose pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.87. | YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.984 |
| alr | CorC_3 | CLOSCI_00611 | CLOSCI_00609 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | CBS domain protein; KEGG: hpa:HPAG1_1423 2.3e-38 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: Cytoplasmic, score: 8.87. | 0.676 |
| alr | ndoA_2 | CLOSCI_00611 | CLOSCI_00610 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Toxin-antitoxin system, toxin component, MazF family; Toxic component of a type II toxin-antitoxin (TA) system. | 0.601 |
| alr | nnr | CLOSCI_00611 | CLOSCI_00612 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.881 |
| alr | rex | CLOSCI_00611 | CLOSCI_00613 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | CoA binding domain protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. | 0.682 |
| alr | tsaE | CLOSCI_00611 | CLOSCI_02143 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Hydrolase, P-loop family; KEGG: cjk:jk1734 6.8e-13 alr; hypothetical protein K01775; COG: COG0802 Predicted ATPase or kinase; Psort location: Cytoplasmic, score: 8.87. | 0.624 |
| cshA | act | CLOSCI_00330 | CLOSCI_01396 | DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | Hydrolase, NUDIX family; KEGG: gka:GK2320 9.4e-33 ADP-ribose pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.87. | 0.936 |
| cshA | groL | CLOSCI_00330 | CLOSCI_00050 | DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.417 |
| cshA | nnr | CLOSCI_00330 | CLOSCI_00612 | DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.976 |
| groL | cshA | CLOSCI_00050 | CLOSCI_00330 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87. | 0.417 |
| groL | hndC_3 | CLOSCI_00050 | CLOSCI_03472 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 4Fe-4S binding domain protein; KEGG: swo:Swol_1701 3.0e-194 NADH dehydrogenase (quinone) K05903; COG: COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; Psort location: Cytoplasmic, score: 9.98. | 0.416 |
| groL | nadE | CLOSCI_00050 | CLOSCI_01169 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.644 |
| groL | nnr | CLOSCI_00050 | CLOSCI_00612 | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.776 |
| hndC_3 | groL | CLOSCI_03472 | CLOSCI_00050 | 4Fe-4S binding domain protein; KEGG: swo:Swol_1701 3.0e-194 NADH dehydrogenase (quinone) K05903; COG: COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; Psort location: Cytoplasmic, score: 9.98. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.416 |
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