Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spoIVAStage IV sporulation protein A; COG: NOG05962 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87. (490 aa)    
Predicted Functional Partners:
EDS08107.1
Stage III sporulation protein AD; COG: NOG13205 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.99.
  
  
 0.927
lytB_2
SpoIID/LytB domain protein; COG: COG2385 Sporulation protein and related proteins.
  
  
 0.895
spoIIID
Sporulation transcriptional regulator SpoIIID; COG: NOG13855 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.878
EDS08104.1
Stage III sporulation protein AA; COG: COG3854 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
  
  
 0.875
EDS08110.1
Putative stage III sporulation protein AG; COG: NOG11553 non supervised orthologous group.
  
  
 0.843
spo0A_1
Sporulation initiation factor Spo0A domain protein; COG: COG0784 FOG: CheY-like receiver; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.843
spo0A_4
Sporulation initiation factor Spo0A domain protein; COG: COG0784 FOG: CheY-like receiver.
  
   
 0.843
spo0A_2
Sporulation initiation factor Spo0A domain protein; COG: COG0784 FOG: CheY-like receiver; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.843
spoIIR
Stage II sporulation protein R; COG: NOG13215 non supervised orthologous group.
  
   
 0.834
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.832
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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