| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDS08426.1 | aroC | CLOSCI_00739 | CLOSCI_00740 | ErfK/YbiS/YcfS/YnhG; KEGG: btl:BALH_4837 2.9e-08 rpoE; DNA-directed RNA polymerase, delta subunit K00960; COG: COG1376 Uncharacterized protein conserved in bacteria. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.516 |
| EDS08426.1 | tgt | CLOSCI_00739 | CLOSCI_00738 | ErfK/YbiS/YcfS/YnhG; KEGG: btl:BALH_4837 2.9e-08 rpoE; DNA-directed RNA polymerase, delta subunit K00960; COG: COG1376 Uncharacterized protein conserved in bacteria. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.683 |
| EDS08426.1 | yajC | CLOSCI_00739 | CLOSCI_00737 | ErfK/YbiS/YcfS/YnhG; KEGG: btl:BALH_4837 2.9e-08 rpoE; DNA-directed RNA polymerase, delta subunit K00960; COG: COG1376 Uncharacterized protein conserved in bacteria. | COG: COG1862 Preprotein translocase subunit YajC. | 0.474 |
| aroC | EDS08426.1 | CLOSCI_00740 | CLOSCI_00739 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | ErfK/YbiS/YcfS/YnhG; KEGG: btl:BALH_4837 2.9e-08 rpoE; DNA-directed RNA polymerase, delta subunit K00960; COG: COG1376 Uncharacterized protein conserved in bacteria. | 0.516 |
| aroC | guaA | CLOSCI_00740 | CLOSCI_03102 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.563 |
| aroC | guaA-2 | CLOSCI_00740 | CLOSCI_03505 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | 0.579 |
| aroC | tgt | CLOSCI_00740 | CLOSCI_00738 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.601 |
| aroC | yajC | CLOSCI_00740 | CLOSCI_00737 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | COG: COG1862 Preprotein translocase subunit YajC. | 0.514 |
| guaA | aroC | CLOSCI_03102 | CLOSCI_00740 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.563 |
| guaA | guaA-2 | CLOSCI_03102 | CLOSCI_03505 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | 0.930 |
| guaA | sun | CLOSCI_03102 | CLOSCI_02807 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.532 |
| guaA | tgt | CLOSCI_03102 | CLOSCI_00738 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.590 |
| guaA | truB | CLOSCI_03102 | CLOSCI_00409 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.829 |
| guaA-2 | aroC | CLOSCI_03505 | CLOSCI_00740 | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.579 |
| guaA-2 | guaA | CLOSCI_03505 | CLOSCI_03102 | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.930 |
| guaA-2 | sun | CLOSCI_03505 | CLOSCI_02807 | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.532 |
| guaA-2 | tgt | CLOSCI_03505 | CLOSCI_00738 | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.590 |
| guaA-2 | truB | CLOSCI_03505 | CLOSCI_00409 | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.829 |
| mreC | secD | CLOSCI_00518 | CLOSCI_01135 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | Export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.540 |
| mreC | tgt | CLOSCI_00518 | CLOSCI_00738 | Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.521 |
STRING v12.5 is now available!
