Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TrxA_2Putative thioredoxin; KEGG: eci:UTI89_C4335 9.8e-15 trxA; thioredoxin 1 K03671; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Cytoplasmic, score: 9.98; Belongs to the thioredoxin family. (119 aa)    
Predicted Functional Partners:
nrdE1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.799
EDS08049.1
Hypothetical protein; Psort location: Extracellular, score: 8.82.
       0.773
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.772
trxA_3
Thioredoxin; KEGG: chy:CHY_0560 6.0e-12 thioredoxin/thioredoxin-disulfide reductase K00384; COG: COG0526 Thiol-disulfide isomerase and thioredoxins; Psort location: Cytoplasmic, score: 8.87; Belongs to the thioredoxin family.
  
     0.710
EDS07337.1
Hypothetical protein; COG: NOG31153 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.697
trxB
KEGG: tte:TTE1881 6.8e-94 trxB; thioredoxin reductase K00384; COG: COG0492 Thioredoxin reductase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.664
trxB-2
KEGG: bha:BH3571 3.0e-68 trxB; thioredoxin reductase (NADPH) K00384; COG: COG0492 Thioredoxin reductase; Psort location: Cytoplasmic, score: 9.98.
  
 
 0.664
trmB
tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
    0.646
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
  
 0.532
copA
Copper-exporting ATPase; KEGG: efa:EF0298 2.0e-194 copper-translocating P-type ATPase K01533; COG: COG2217 Cation transport ATPase; Psort location: CytoplasmicMembrane, score: 9.99.
 
  
 0.500
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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