Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folCBifunctional protein FolC; KEGG: tte:TTE0783 2.7e-74 folC; Folylpolyglutamate synthase K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 8.87. (430 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.998
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.953
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
    
 0.921
folC-2
Bifunctional protein FolC; KEGG: gka:GK2637 1.0e-58 folyl-polyglutamate synthetase K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.920
folA-2
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.911
folE
GTP cyclohydrolase I; KEGG: cpe:CPE1019 4.3e-60 mtrA; GTP cyclohydrolase K01495; COG: COG0302 GTP cyclohydrolase I; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.845
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.845
rny_3
HDIG domain protein; COG: COG1418 Predicted HD superfamily hydrolase; Psort location: Cytoplasmic, score: 8.87.
 
   
 0.698
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.620
fhs
KEGG: chy:CHY_2385 2.7e-202 fhs; formate--tetrahydrofolate ligase K01938; COG: COG2759 Formyltetrahydrofolate synthetase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.605
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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