close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ydfJHypothetical protein; COG: COG1033 Predicted exporters of the RND superfamily; Psort location: CytoplasmicMembrane, score: 9.99. (704 aa)    
Predicted Functional Partners:
EDS07693.1
Hypothetical protein; KEGG: ana:alr1121 5.7e-08 two-component hybrid sensor and regulator; COG: COG2409 Predicted drug exporters of the RND superfamily.
   
 0.975
yvdT_2
Transcriptional regulator, TetR family; KEGG: bcl:ABC2937 0.00028 NADH dehydrogenase K03885; COG: COG1309 Transcriptional regulator; Psort location: Cytoplasmic, score: 8.87.
 
     0.846
EDS07690.1
Hypothetical protein.
       0.499
nadE
NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
       0.496
DesVI
Methyltransferase domain protein; KEGG: bce:BC4326 3.0e-45 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: Cytoplasmic, score: 8.87.
       0.494
hslO
Chaperonin HslO; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
       0.487
EDS07697.1
Oxidoreductase; COG: NOG16874 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
       0.473
mprF-2
Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
 
     0.439
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.