| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDS07714.1 | LplA | CLOSCI_01187 | CLOSCI_01186 | Hypothetical protein; KEGG: noc:Noc_1415 0.0011 NUDIX hydrolase K01518. | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | 0.773 |
| EDS07714.1 | dnaK | CLOSCI_01187 | CLOSCI_01190 | Hypothetical protein; KEGG: noc:Noc_1415 0.0011 NUDIX hydrolase K01518. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.441 |
| EDS07714.1 | grpE | CLOSCI_01187 | CLOSCI_01189 | Hypothetical protein; KEGG: noc:Noc_1415 0.0011 NUDIX hydrolase K01518. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.520 |
| EDS07714.1 | hrcA | CLOSCI_01187 | CLOSCI_01188 | Hypothetical protein; KEGG: noc:Noc_1415 0.0011 NUDIX hydrolase K01518. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.520 |
| LplA | EDS07714.1 | CLOSCI_01186 | CLOSCI_01187 | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | Hypothetical protein; KEGG: noc:Noc_1415 0.0011 NUDIX hydrolase K01518. | 0.773 |
| LplA | birA | CLOSCI_01186 | CLOSCI_00957 | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.471 |
| LplA | dnaK | CLOSCI_01186 | CLOSCI_01190 | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.586 |
| LplA | grpE | CLOSCI_01186 | CLOSCI_01189 | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.548 |
| LplA | hrcA | CLOSCI_01186 | CLOSCI_01188 | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.531 |
| birA | LplA | CLOSCI_00957 | CLOSCI_01186 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | KEGG: ctc:CTC02045 6.4e-66 lipoate-protein ligase A K03800; COG: COG0095 Lipoate-protein ligase A; Psort location: Cytoplasmic, score: 9.98. | 0.471 |
| birA | dnaK | CLOSCI_00957 | CLOSCI_01190 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.469 |
| birA | groS | CLOSCI_00957 | CLOSCI_00049 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.614 |
| birA | hrcA | CLOSCI_00957 | CLOSCI_01188 | biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.526 |
| dnaJ | dnaK | CLOSCI_01191 | CLOSCI_01190 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |
| dnaJ | groL | CLOSCI_01191 | CLOSCI_00050 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.808 |
| dnaJ | groS | CLOSCI_01191 | CLOSCI_00049 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.617 |
| dnaJ | grpE | CLOSCI_01191 | CLOSCI_01189 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.960 |
| dnaJ | hrcA | CLOSCI_01191 | CLOSCI_01188 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.768 |
| dnaJ_1 | dnaK | CLOSCI_00879 | CLOSCI_01190 | Putative chaperone protein DnaJ; KEGG: cme:CMJ043C 5.2e-07 phycocyanobilin lyase alpha subunit K02288; COG: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; Psort location: Cytoplasmic, score: 9.65. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
| dnaJ_1 | groL | CLOSCI_00879 | CLOSCI_00050 | Putative chaperone protein DnaJ; KEGG: cme:CMJ043C 5.2e-07 phycocyanobilin lyase alpha subunit K02288; COG: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; Psort location: Cytoplasmic, score: 9.65. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.798 |
