| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FchA | gcvH | CLOSCI_01260 | CLOSCI_01256 | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.864 |
| FchA | gcvPA | CLOSCI_01260 | CLOSCI_01257 | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.759 |
| FchA | gcvPB | CLOSCI_01260 | CLOSCI_01258 | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | Putative glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.788 |
| FchA | gcvT | CLOSCI_01260 | CLOSCI_01255 | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.971 |
| FchA | lpdA | CLOSCI_01260 | CLOSCI_01259 | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | Dihydrolipoyl dehydrogenase; KEGG: chy:CHY_0713 8.1e-98 lpdA; alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score: 9.98. | 0.843 |
| gcvH | FchA | CLOSCI_01256 | CLOSCI_01260 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | 0.864 |
| gcvH | gcvPA | CLOSCI_01256 | CLOSCI_01257 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| gcvH | gcvPB | CLOSCI_01256 | CLOSCI_01258 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Putative glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcvH | gcvT | CLOSCI_01256 | CLOSCI_01255 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvH | glyA | CLOSCI_01256 | CLOSCI_00072 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
| gcvH | lpdA | CLOSCI_01256 | CLOSCI_01259 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoyl dehydrogenase; KEGG: chy:CHY_0713 8.1e-98 lpdA; alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score: 9.98. | 0.994 |
| gcvH | lpdA-2 | CLOSCI_01256 | CLOSCI_04033 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoyl dehydrogenase; KEGG: tde:TDE1629 2.0e-78 lpdA; dihydrolipoamide dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score: 9.98. | 0.980 |
| gcvPA | FchA | CLOSCI_01257 | CLOSCI_01260 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | 0.759 |
| gcvPA | gcvH | CLOSCI_01257 | CLOSCI_01256 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| gcvPA | gcvPB | CLOSCI_01257 | CLOSCI_01258 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Putative glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcvPA | gcvT | CLOSCI_01257 | CLOSCI_01255 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvPA | glyA | CLOSCI_01257 | CLOSCI_00072 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
| gcvPA | lpdA | CLOSCI_01257 | CLOSCI_01259 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Dihydrolipoyl dehydrogenase; KEGG: chy:CHY_0713 8.1e-98 lpdA; alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score: 9.98. | 0.990 |
| gcvPA | lpdA-2 | CLOSCI_01257 | CLOSCI_04033 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Dihydrolipoyl dehydrogenase; KEGG: tde:TDE1629 2.0e-78 lpdA; dihydrolipoamide dehydrogenase K00382; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: Cytoplasmic, score: 9.98. | 0.963 |
| gcvPB | FchA | CLOSCI_01258 | CLOSCI_01260 | Putative glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Formiminotransferase-cyclodeaminase; KEGG: chy:CHY_1879 1.3e-42 fchA2; methenyltetrahydrofolate cyclohydrolase K01491; COG: COG3404 Methenyl tetrahydrofolate cyclohydrolase. | 0.788 |
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