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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pncAIsochorismatase family protein; KEGG: pab:PAB1720 3.7e-15 nicotinamidase K01440; COG: COG1335 Amidases related to nicotinamidase; Psort location: Cytoplasmic, score: 8.87. (179 aa)    
Predicted Functional Partners:
pncB
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.976
cobB-2
Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 0.921
rihA
KEGG: cpf:CPF_2260 1.2e-50 nucleoside hydrolase, IunH family K01239; COG: COG1957 Inosine-uridine nucleoside N-ribohydrolase; Psort location: Cytoplasmic, score: 8.87.
     
 0.912
rihB
KEGG: efa:EF2587 2.6e-12 inosine-uridine preferring nucleoside hydrolase K01239; COG: COG1957 Inosine-uridine nucleoside N-ribohydrolase; Psort location: Cytoplasmic, score: 8.87.
     
 0.912
deoD
KEGG: bcl:ABC4021 1.3e-76 deoD; purine-nucleoside phosphorylase K03784; COG: COG0813 Purine-nucleoside phosphorylase; Psort location: Cytoplasmic, score: 8.87.
    
  0.902
crcB
Protein CrcB; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
  
    0.805
SrfAA
AMP-binding enzyme; KEGG: ava:Ava_1613 5.8e-204 non-ribosomal peptide synthase K00644; COG: COG1020 Non-ribosomal peptide synthetase modules and related proteins; Psort location: Cytoplasmic, score: 9.96; Belongs to the ATP-dependent AMP-binding enzyme family.
  
  
 0.803
nadE
NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.715
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
   
 0.687
nadC
Nicotinate-nucleotide diphosphorylase (carboxylating); KEGG: fnu:FN0010 2.0e-85 nicotinate-nucleotide pyrophosphorylase K00767; COG: COG0157 Nicotinate-nucleotide pyrophosphorylase; Psort location: Cytoplasmic, score: 9.98; Belongs to the NadC/ModD family.
  
 
 0.660
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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