Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
aprXPeptidase, S8/S53 family; KEGG: mba:Mbar_A1626 6.2e-35 hypothetical protein; COG: COG1404 Subtilisin-like serine proteases; Psort location: Extracellular, score: 8.10; Belongs to the peptidase S8 family. (297 aa)    
Predicted Functional Partners:
kdpD_5
ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein; KEGG: lin:pli0050 9.7e-221 similar to the two components sensor protein kdpD K07646; COG: COG2205 Osmosensitive K+ channel histidine kinase; Psort location: CytoplasmicMembrane, score: 9.99.
   
   0.724
kdpE_4
Response regulator receiver domain protein; KEGG: eci:UTI89_C0698 1.1e-47 kdpE; transcriptional regulatory protein KdpE K07667; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: Cytoplasmic, score: 9.98.
       0.714
kdpC
K+-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
  
    0.665
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
    0.645
EDS07510.1
Helix-turn-helix protein, YlxM/p13 family; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
       0.642
kdpB
K+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
       0.597
kdpA
K+-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.
       0.578
EDS06649.1
Hypothetical protein; COG: NOG11305 non supervised orthologous group.
  
     0.486
rpsP
COG: COG0228 Ribosomal protein S16; Psort location: Cytoplasmic, score: 8.87; Belongs to the bacterial ribosomal protein bS16 family.
       0.485
EDS07513.1
Hypothetical protein; COG: COG1837 Predicted RNA-binding protein (contains KH domain); Psort location: Cytoplasmic, score: 8.87; Belongs to the UPF0109 family.
       0.482
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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