Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
actHydrolase, NUDIX family; KEGG: gka:GK2320 9.4e-33 ADP-ribose pyrophosphatase K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.87. (181 aa)    
Predicted Functional Partners:
nnr
YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...]
  
 0.967
cshA
DEAD/DEAH box helicase; KEGG: eci:UTI89_C3590 4.4e-99 deaD, csdA, mssB, rhlD; cold-shock DEAD-box protein A K05592; COG: COG0513 Superfamily II DNA and RNA helicases; Psort location: Cytoplasmic, score: 8.87.
  
 0.926
deoB
Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
    
  0.915
prs
Ribose-phosphate diphosphokinase; KEGG: cac:CAC0819 1.3e-97 phosphoribosylpyrophosphate synthetase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase; Psort location: Cytoplasmic, score: 8.87; Belongs to the ribose-phosphate pyrophosphokinase family.
    
 0.907
prs-2
KEGG: cpr:CPR_1519 1.4e-100 prs; ribose-phosphate pyrophosphokinase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase; Psort location: Cytoplasmic, score: 8.87.
    
 0.907
pgcA
Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; KEGG: cac:CAC2337 6.6e-167 phosphomannomutase K01840; COG: COG1109 Phosphomannomutase; Psort location: Cytoplasmic, score: 8.87.
  
  0.904
thiM
Putative hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
     
  0.900
rnr
Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
   
 0.847
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.735
EDS07587.1
Hypothetical protein; COG: COG1300 Uncharacterized membrane protein; Psort location: CytoplasmicMembrane, score: 9.99.
       0.713
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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