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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nifSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (394 aa)    
Predicted Functional Partners:
nifU
Fe-S iron-sulfur cluster assembly protein, NifU family; KEGG: rxy:Rxyl_1354 1.2e-21 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: Cytoplasmic, score: 8.87.
 
 0.992
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.966
EDS06626.1
Hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 0.957
ThiF
ThiF family protein; KEGG: eca:ECA0230 1.2e-34 thiF; thiamine biosynthesis adenylyltransferase K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; Psort location: Cytoplasmic, score: 8.87.
   
 0.930
ynjE
Rhodanese-like protein; KEGG: cpf:CPF_1308 2.5e-87 putative thiosulfate sulfurtransferase K01010; COG: COG2897 Rhodanese-related sulfurtransferase.
  
 0.914
EDS05411.1
Rhodanese-like protein; KEGG: cyb:CYB_2710 1.0e-33 rhdA; thiosulfate sulfurtransferase K01010; COG: COG2897 Rhodanese-related sulfurtransferase; Psort location: Cytoplasmic, score: 8.87.
  
 0.914
iscS_2
Aminotransferase, class V; KEGG: tte:TTE1663 8.8e-101 nifS; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes K04487; COG: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Psort location: Cytoplasmic, score: 8.87.
  
  
 
0.909
trmU
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.888
CymR_2
Transcriptional regulator, Rrf2 family; KEGG: ama:AM656 9.9e-10 aminotransferase, class V K04487; COG: COG1959 Predicted transcriptional regulator; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.869
EDS08353.1
Hypothetical protein; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: Cytoplasmic, score: 8.87.
  
 0.862
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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