| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDS06437.1 | nagA | CLOSCI_02386 | CLOSCI_01435 | comF family protein; KEGG: reh:H16_A0339 2.1e-21 predicted amidophosphoribosyltransferase; COG: COG1040 Predicted amidophosphoribosyltransferases; Psort location: Cytoplasmic, score: 8.87. | KEGG: tte:TTE0232 6.9e-69 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: Cytoplasmic, score: 8.87. | 0.682 |
| EDS07333.1 | bglK | CLOSCI_01432 | CLOSCI_01433 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | 0.781 |
| EDS07333.1 | nagA | CLOSCI_01432 | CLOSCI_01435 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. | KEGG: tte:TTE0232 6.9e-69 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: Cytoplasmic, score: 8.87. | 0.694 |
| EDS07333.1 | nanA | CLOSCI_01432 | CLOSCI_01429 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. | KEGG: spn:SP_1676 1.1e-118 N-acetylneuraminate lyase K01639; COG: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Psort location: Cytoplasmic, score: 8.87. | 0.439 |
| EDS07333.1 | ybbH_3 | CLOSCI_01432 | CLOSCI_01434 | Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. | SIS domain protein; KEGG: cac:CAC0397 6.0e-08 predicted sugar phosphate aminotransferase involved in capsule formation K08094; COG: COG1737 Transcriptional regulators; Psort location: Cytoplasmic, score: 8.87. | 0.746 |
| FruA | bglK | CLOSCI_02921 | CLOSCI_01433 | KEGG: cpr:CPR_0550 3.4e-163 fructose specific permease K00890; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score: 10.00. | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | 0.496 |
| FruA | nagA | CLOSCI_02921 | CLOSCI_01435 | KEGG: cpr:CPR_0550 3.4e-163 fructose specific permease K00890; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score: 10.00. | KEGG: tte:TTE0232 6.9e-69 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: Cytoplasmic, score: 8.87. | 0.710 |
| FruA | nagB | CLOSCI_02921 | CLOSCI_03190 | KEGG: cpr:CPR_0550 3.4e-163 fructose specific permease K00890; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score: 10.00. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.580 |
| bglK | EDS07333.1 | CLOSCI_01433 | CLOSCI_01432 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | Hypothetical protein; Psort location: Cytoplasmic, score: 8.87. | 0.781 |
| bglK | FruA | CLOSCI_01433 | CLOSCI_02921 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | KEGG: cpr:CPR_0550 3.4e-163 fructose specific permease K00890; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: CytoplasmicMembrane, score: 10.00. | 0.496 |
| bglK | nagA | CLOSCI_01433 | CLOSCI_01435 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | KEGG: tte:TTE0232 6.9e-69 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: Cytoplasmic, score: 8.87. | 0.794 |
| bglK | nagB | CLOSCI_01433 | CLOSCI_03190 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.438 |
| bglK | nanA | CLOSCI_01433 | CLOSCI_01429 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | KEGG: spn:SP_1676 1.1e-118 N-acetylneuraminate lyase K01639; COG: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Psort location: Cytoplasmic, score: 8.87. | 0.653 |
| bglK | nanE | CLOSCI_01433 | CLOSCI_01428 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | Putative N-acetylmannosamine-6-phosphate epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.743 |
| bglK | ybbH_3 | CLOSCI_01433 | CLOSCI_01434 | ROK family protein; KEGG: spj:MGAS2096_Spy0236 3.9e-91 N-acetylmannosamine kinase / transcriptional regulator K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: Cytoplasmic, score: 9.98. | SIS domain protein; KEGG: cac:CAC0397 6.0e-08 predicted sugar phosphate aminotransferase involved in capsule formation K08094; COG: COG1737 Transcriptional regulators; Psort location: Cytoplasmic, score: 8.87. | 0.791 |
| glmM | glmS | CLOSCI_04009 | CLOSCI_00153 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.956 |
| glmM | nagA | CLOSCI_04009 | CLOSCI_01435 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | KEGG: tte:TTE0232 6.9e-69 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: Cytoplasmic, score: 8.87. | 0.935 |
| glmM | nagB | CLOSCI_04009 | CLOSCI_03190 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. | 0.942 |
| glmS | glmM | CLOSCI_00153 | CLOSCI_04009 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.956 |
| glmS | nagA | CLOSCI_00153 | CLOSCI_01435 | Glutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | KEGG: tte:TTE0232 6.9e-69 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: Cytoplasmic, score: 8.87. | 0.940 |