STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
niaRHTH domain protein; KEGG: mac:MA0676 2.3e-06 bpl, birA; biotin operon repressor/biotin-pyruvate carboxylase ligase K03524:K01947; COG: COG1827 Predicted small molecule binding protein (contains 3H domain); Psort location: Cytoplasmic, score: 8.87. (171 aa)    
Predicted Functional Partners:
nadC
Nicotinate-nucleotide diphosphorylase (carboxylating); KEGG: fnu:FN0010 2.0e-85 nicotinate-nucleotide pyrophosphorylase K00767; COG: COG0157 Nicotinate-nucleotide pyrophosphorylase; Psort location: Cytoplasmic, score: 9.98; Belongs to the NadC/ModD family.
 
  
 0.837
NadB
FAD binding domain protein; KEGG: fnu:FN0009 4.8e-100 L-aspartate oxidase K00278; COG: COG0029 Aspartate oxidase; Psort location: Cytoplasmic, score: 9.36.
 
  
 0.827
nadA
Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
  
 0.814
birA
biotin--[acetyl-CoA-carboxylase] ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.773
opuBA
Hypothetical protein; KEGG: pen:PSEEN3440 7.1e-10 ABC transporter, ATP-binding protein; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: Cytoplasmic, score: 8.87.
       0.652
ThiT
Putative proton-coupled thiamine transporter YuaJ; COG: COG3859 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.99.
  
   
 0.606
panT
COG: COG4684 Predicted membrane protein; Psort location: CytoplasmicMembrane, score: 9.99.
 
   
 0.588
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
      
 0.532
thiH
Thiazole biosynthesis protein ThiH; KEGG: mac:MA0154 5.7e-14 bioB; biotin synthase K01012; COG: COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes; Psort location: Cytoplasmic, score: 8.87.
      
 0.471
mprF-2
Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
       0.465
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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