Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
proC-2Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (281 aa)    
Predicted Functional Partners:
EDS06623.1
KEGG: bce:BC2835 1.2e-66 proline racemase K01777; COG: COG3938 Proline racemase; Psort location: Cytoplasmic, score: 8.87.
    
 0.912
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
  
  
 
0.909
cutC_1
Putative formate C-acetyltransferase; KEGG: gsu:GSU2101 4.5e-239 formate acetyltransferase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: Cytoplasmic, score: 9.98.
    
 0.904
pepIP_1
Proline-specific peptidase; Releases the N-terminal proline from various substrates. Belongs to the peptidase S33 family.
    
  0.901
pepIP_2
Hypothetical protein; KEGG: ldb:Ldb1896 5.6e-19 pepIP; proline iminopeptidase K01259; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
    
  0.901
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 
 0.768
proA
Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.721
gntR_1
Transcriptional regulator, GntR family; KEGG: msm:MSMEG_3400 6.6e-06 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators.
       0.521
PurL
Phosphoribosylformylglycinamidine synthase; KEGG: cac:CAC1655 0. purQ, purL; bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain/glutamine amidotransferase domain) K01952; COG: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Psort location: Cytoplasmic, score: 8.87.
     
 0.466
EDS07257.1
Hypothetical protein; COG: NOG32083 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
       0.465
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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