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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoTHD domain protein; KEGG: sat:SYN_03611 5.4e-30 GTP pyrophosphokinase / guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase K00951:K01139; COG: COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; Psort location: Cytoplasmic, score: 8.87. (178 aa)    
Predicted Functional Partners:
nrdD-2
KEGG: tde:TDE1331 2.6e-220 nrdD; anaerobic ribonucleoside triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.87.
    
 0.928
relA
RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
  
 
0.920
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.916
gmk_1
Hypothetical protein; KEGG: tws:TW406 1.8e-09 gmk; guanylate kinase K00942; COG: COG0194 Guanylate kinase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.916
YwaC
RelA/SpoT domain protein; KEGG: bce:BC4341 3.4e-51 GTP pyrophosphokinase K00951; COG: COG2357 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
    
 0.915
pyk-2
Pyruvate kinase; KEGG: tte:TTE1815 8.7e-133 pykF; pyruvate kinase K00873; COG: COG0469 Pyruvate kinase; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.913
nrdE1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.908
pyk
Pyruvate kinase; KEGG: tte:TTE1815 1.2e-137 pykF; pyruvate kinase K00873; COG: COG0469 Pyruvate kinase; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.903
nrdD
KEGG: lla:L70400 2.3e-116 nrdD; anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.87.
     
 0.900
nrdB
Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
 0.900
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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