| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GuaB_1 | apt | CLOSCI_02937 | CLOSCI_01137 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.451 |
| GuaB_1 | guaA | CLOSCI_02937 | CLOSCI_03102 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.995 |
| GuaB_1 | guaA-2 | CLOSCI_02937 | CLOSCI_03505 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | 0.996 |
| GuaB_1 | guaB | CLOSCI_02937 | CLOSCI_00052 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.945 |
| GuaB_1 | hpt | CLOSCI_02937 | CLOSCI_01994 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | KEGG: tte:TTE2394 2.0e-53 hpt; hypoxanthine-guanine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.916 |
| GuaB_1 | rdgB | CLOSCI_02937 | CLOSCI_02343 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.940 |
| GuaB_1 | xpt | CLOSCI_02937 | CLOSCI_01698 | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.943 |
| apt | GuaB_1 | CLOSCI_01137 | CLOSCI_02937 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | KEGG: lin:lin0179 3.1e-217 similar to inosine monophosphate dehydrogenase K00088; COG: COG0516 IMP dehydrogenase/GMP reductase; Psort location: Cytoplasmic, score: 8.87. | 0.451 |
| apt | gmk | CLOSCI_01137 | CLOSCI_00672 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.946 |
| apt | gmk_1 | CLOSCI_01137 | CLOSCI_02679 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypothetical protein; KEGG: tws:TW406 1.8e-09 gmk; guanylate kinase K00942; COG: COG0194 Guanylate kinase; Psort location: Cytoplasmic, score: 8.87. | 0.945 |
| apt | guaA | CLOSCI_01137 | CLOSCI_03102 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.983 |
| apt | guaA-2 | CLOSCI_01137 | CLOSCI_03505 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | 0.983 |
| apt | guaB | CLOSCI_01137 | CLOSCI_00052 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.525 |
| apt | guaD | CLOSCI_01137 | CLOSCI_02894 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative guanine deaminase; KEGG: cac:CAC0282 1.1e-104 cytosine/guanine deaminase related protein K01487; COG: COG0402 Cytosine deaminase and related metal-dependent hydrolases; Psort location: Cytoplasmic, score: 8.87. | 0.912 |
| apt | hpt | CLOSCI_01137 | CLOSCI_01994 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | KEGG: tte:TTE2394 2.0e-53 hpt; hypoxanthine-guanine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.98; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.929 |
| apt | xpt | CLOSCI_01137 | CLOSCI_01698 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.950 |
| gmk | apt | CLOSCI_00672 | CLOSCI_01137 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.946 |
| gmk | gmk_1 | CLOSCI_00672 | CLOSCI_02679 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypothetical protein; KEGG: tws:TW406 1.8e-09 gmk; guanylate kinase K00942; COG: COG0194 Guanylate kinase; Psort location: Cytoplasmic, score: 8.87. | 0.900 |
| gmk | guaA | CLOSCI_00672 | CLOSCI_03102 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.959 |
| gmk | guaA-2 | CLOSCI_00672 | CLOSCI_03505 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolyzing) domain protein; KEGG: bth:BT2419 2.8e-184 putative GMP synthase [glutamine-hydrolyzing] K01951; COG: COG0518 GMP synthase - Glutamine amidotransferase domain; Psort location: Cytoplasmic, score: 8.87. | 0.957 |
STRING v12.5 is now available!
