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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
baiABile acid 7-dehydroxylase 1/3; KEGG: cpr:CPR_0991 9.5e-56 7-alpha-hydroxysteroid dehydrogenase K00076; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: Cytoplasmic, score: 9.98; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)    
Predicted Functional Partners:
fabF
Beta-ketoacyl-acyl-carrier-protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 0.966
fabZ
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
 
 0.951
fabHA
Beta-ketoacyl-acyl-carrier-protein synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.944
baiE
KEGG: msm:MSMEG_2245 1.9e-11 bile-acid 7-alpha dehydratase; COG: NOG20037 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.87.
 
 
 0.740
fabD
[acyl-carrier-protein] S-malonyltransferase; KEGG: cac:CAC3575 2.1e-74 fabD; malonyl CoA-acyl carrier protein transacylase K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: Cytoplasmic, score: 8.87.
 
 0.673
BaiB
AMP-binding enzyme; KEGG: hne:HNE_0099 1.1e-68 baiB; bile acid-coenzyme A ligase; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: Cytoplasmic, score: 9.96.
 
 
 0.625
baiF
Bile acid-CoA hydrolase; KEGG: ecs:ECs0041 1.2e-66 crotonobetainyl-CoA:carnitine CoA-transferase K08298; COG: COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Psort location: Cytoplasmic, score: 9.98; Belongs to the CoA-transferase III family.
  
 
 
 0.578
SrfAA
AMP-binding enzyme; KEGG: ava:Ava_1613 5.8e-204 non-ribosomal peptide synthase K00644; COG: COG1020 Non-ribosomal peptide synthetase modules and related proteins; Psort location: Cytoplasmic, score: 9.96; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.560
accD
acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
 
  
 0.530
EDS08828.1
Arylsulfatase; KEGG: ecj:JW3654 2.9e-109 yidJ; predicted sulfatase/phosphatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: Cytoplasmic, score: 8.87.
   
 
 0.505
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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