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query proteins and first shell of interactors
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folA-2Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (174 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.994
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.920
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
  
 
0.918
fhs
KEGG: chy:CHY_2385 2.7e-202 fhs; formate--tetrahydrofolate ligase K01938; COG: COG2759 Formyltetrahydrofolate synthetase; Psort location: Cytoplasmic, score: 8.87.
  
 
 0.913
metH_3
KEGG: ctc:CTC01806 1.4e-203 5-methyltetrahydrofolate--homocysteine methyltransferase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.87.
    
 0.912
folC
Bifunctional protein FolC; KEGG: tte:TTE0783 2.7e-74 folC; Folylpolyglutamate synthase K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 8.87.
     
 0.911
folC-2
Bifunctional protein FolC; KEGG: gka:GK2637 1.0e-58 folyl-polyglutamate synthetase K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 8.87.
     
 0.911
thyX
Hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.909
purH
AICARFT/IMPCHase bienzyme; KEGG: sce:YLR028C 1.4e-125 ADE16; AICAR transformylase/IMP cyclohydrolase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.87.
    
 0.905
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.905
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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