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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ogt6-O-methylguanine DNA methyltransferase, DNA binding domain protein; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (182 aa)    
Predicted Functional Partners:
alkA
Base excision DNA repair protein, HhH-GPD family; KEGG: mpu:MYPU_0950 1.2e-50 ogt; methylated-DNA--protein-cysteine methyltransferase (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase) K00567:K01247; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: Cytoplasmic, score: 8.87.
 
  
 0.914
tag
KEGG: pha:PSHAa0788 4.5e-42 tag; 3-methyl-adenine DNA glycosylase I K01246; COG: COG2818 3-methyladenine DNA glycosylase; Psort location: Cytoplasmic, score: 8.87.
   
 0.711
EDS05792.1
Hypothetical protein; COG: NOG21554 non supervised orthologous group.
       0.609
EDS05790.1
Hypothetical protein; KEGG: zmo:ZMO0053 2.3e-15 pcaD; putative beta-ketoadipate enol-lactone hydrolase K01055; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: Cytoplasmic, score: 8.87.
  
    0.506
cynR_2
LysR substrate binding domain protein; KEGG: shn:Shewana3_3435 8.0e-14 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: Cytoplasmic, score: 9.98; Belongs to the LysR transcriptional regulatory family.
       0.444
cinA_2
Competence/damage-inducible domain protein CinA; KEGG: hsa:80308 5.5e-07 FLAD1; FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: Cytoplasmic, score: 8.87; Belongs to the CinA family.
 
     0.417
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
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