Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gdpPDHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. (688 aa)    
Predicted Functional Partners:
rplI
Ribosomal protein L9; Binds to the 23S rRNA.
 
  
 0.934
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
  
  
 0.832
EDS06441.1
YbbR-like protein; COG: COG4856 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87.
  
   
 0.636
polC
DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
     0.625
yfiC
Methyltransferase domain protein; KEGG: ctc:CTC00225 2.9e-54 methyltransferase K00599; COG: COG4123 Predicted O-methyltransferase; Psort location: Cytoplasmic, score: 8.87.
  
     0.599
tmcAL
Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
  
     0.575
trmK
Hypothetical protein; KEGG: fnu:FN0907 0.0071 ribosomal RNA small subunit methyltransferase C K00564; COG: COG2384 Predicted SAM-dependent methyltransferase; Psort location: Cytoplasmic, score: 8.87.
  
     0.575
cdaA
TIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
  
   
 0.570
EDS08711.1
COG: COG4472 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.87; Belongs to the UPF0297 family.
  
     0.555
galE
KEGG: bsu:BG11837 1.3e-124 galE; UDP-glucose 4-epimerase K01784; COG: COG1087 UDP-glucose 4-epimerase; Psort location: Cytoplasmic, score: 8.87; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
       0.486
Your Current Organism:
Clostridium scindens
NCBI taxonomy Id: 411468
Other names: Clostridium scindens ATCC 35704, [. scindens ATCC 35704, [Clostridium] scindens ATCC 35704
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.