| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SirC | cbiD | CLOSCI_03615 | CLOSCI_03591 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.891 |
| SirC | cbiG | CLOSCI_03615 | CLOSCI_03594 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | CbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. | 0.941 |
| SirC | cbiK | CLOSCI_03615 | CLOSCI_03613 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | Cobalt chelatase (CbiK); KEGG: lin:lin1165 4.1e-55 cbiK; similar to anaerobic Cobalt Chelatase In Cobalamin Biosynthesis K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: Cytoplasmic, score: 8.87. | 0.999 |
| SirC | cbiM | CLOSCI_03615 | CLOSCI_03609 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | 0.884 |
| SirC | cbiN | CLOSCI_03615 | CLOSCI_03610 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. | 0.670 |
| SirC | cobI | CLOSCI_03615 | CLOSCI_03592 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | KEGG: mst:Msp_0038 1.4e-31 cbiL; CbiL K03394; COG: COG2243 Precorrin-2 methylase; Psort location: Cytoplasmic, score: 8.87; Belongs to the precorrin methyltransferase family. | 0.995 |
| SirC | cobK | CLOSCI_03615 | CLOSCI_03596 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | precorrin-6A reductase; KEGG: ctc:CTC00734 5.1e-57 cbiT; precorrin-6B methylase/decarboxylase cbiT/cbiE K03399:K02191; COG: COG2241 Precorrin-6B methylase 1; Psort location: Cytoplasmic, score: 8.87. | 0.932 |
| SirC | hemC | CLOSCI_03615 | CLOSCI_03616 | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
| cbiD | SirC | CLOSCI_03591 | CLOSCI_03615 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | 0.891 |
| cbiD | cbiG | CLOSCI_03591 | CLOSCI_03594 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | CbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. | 0.999 |
| cbiD | cbiK | CLOSCI_03591 | CLOSCI_03613 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalt chelatase (CbiK); KEGG: lin:lin1165 4.1e-55 cbiK; similar to anaerobic Cobalt Chelatase In Cobalamin Biosynthesis K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: Cytoplasmic, score: 8.87. | 0.992 |
| cbiD | cbiM | CLOSCI_03591 | CLOSCI_03609 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. | 0.700 |
| cbiD | cbiN | CLOSCI_03591 | CLOSCI_03610 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalt transport protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. | 0.675 |
| cbiD | cbiQ | CLOSCI_03591 | CLOSCI_03611 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: CytoplasmicMembrane, score: 9.99. | 0.619 |
| cbiD | cobI | CLOSCI_03591 | CLOSCI_03592 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | KEGG: mst:Msp_0038 1.4e-31 cbiL; CbiL K03394; COG: COG2243 Precorrin-2 methylase; Psort location: Cytoplasmic, score: 8.87; Belongs to the precorrin methyltransferase family. | 0.980 |
| cbiD | cobK | CLOSCI_03591 | CLOSCI_03596 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | precorrin-6A reductase; KEGG: ctc:CTC00734 5.1e-57 cbiT; precorrin-6B methylase/decarboxylase cbiT/cbiE K03399:K02191; COG: COG2241 Precorrin-6B methylase 1; Psort location: Cytoplasmic, score: 8.87. | 0.996 |
| cbiD | hemC | CLOSCI_03591 | CLOSCI_03616 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.807 |
| cbiG | SirC | CLOSCI_03594 | CLOSCI_03615 | CbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. | Siroheme synthase domain protein; KEGG: aae:aq_1237 6.8e-23 cysG; precorrin-2 oxidase. | 0.941 |
| cbiG | cbiD | CLOSCI_03594 | CLOSCI_03591 | CbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.999 |
| cbiG | cbiK | CLOSCI_03594 | CLOSCI_03613 | CbiG; KEGG: dde:Dde_3181 1.8e-33 precorrin-3B C17-methyltransferase K02189:K03395:K00594; COG: COG2073 Cobalamin biosynthesis protein CbiG; Psort location: Cytoplasmic, score: 8.87. | Cobalt chelatase (CbiK); KEGG: lin:lin1165 4.1e-55 cbiK; similar to anaerobic Cobalt Chelatase In Cobalamin Biosynthesis K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: Cytoplasmic, score: 8.87. | 0.995 |